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Dirección de Estudios de Posgrado

Seminario programado

Seminario del Departamento de Microbiología

Seminario del Departamento de Microbiología

Paper Review: Facultative heterochromatin mediated by core and accessory chromosome-encoded H3K27-specific methyltransferases controls virulence in a fungal phytopathogen………. Ricardo Rodríguez Vargas, M.Sc…………This work reveals that Fusarium oxysporum f. sp. lycopersici(Fol4287) encodes three H3K27-specific methyltransferases (Kmt6a/b/c), with Kmt6a on a core chromosome and Kmt6b/c on an accessory chromosome, providing the first functional evidence that accessory chromosome encode histone modifiers that contribute to the global epigenetic landscape. Through integrated RNA-seq and ChIP-seq analyses, the authors show that Ash1-mediated H3K36me3 and Kmt6a-mediated H3K27me3 cooperate to silence genes located in facultative heterochromatin, including in planta–induced effectors. The deletion of KMT6A abolishes H3K27me3 in central chromosomal regions, massively derepresses effector and virulence-associated genes under axenic conditions, and causes complete loss of pathogenicity on tomato while leaving larva virulence intact. Also, constitutive overexpression of the effector-activating transcription factor FTF1 restores SIX effector expression in theΔkmt6a background in planta but does not rescue virulence, implying that additional Kmt6a-dependent, heterochromatin-regulated factors are essential for plant infection……….. Doi:https://doi.org/10.1093/nar/gkaf1441...........https://cicese.zoom.us/j/87006389972?pwd=9sWluAL27rbgpZEqYcJFkuYZgo8Qcr.1

Lugar: Auditorio Ildiko Bartnicki

Fecha: 11-02-2026

Hora: 09:00 am